Neuronal cholesterol esterification by ACAT1 in Alzheimer's disease

✍ Scribed by Ta-Yuan Chang; Catherine C. Y. Chang; Elena Bryleva; Maximillian A. Rogers; Stephanie R. Murphy

• Book ID: 102281769
• Publisher: John Wiley and Sons
• Year: 2010
• Tongue: English
• Weight: 143 KB
• Volume: 62
• Category: Article
• ISSN: 1521-6543
• DOI: 10.1002/iub.305

✦ Synopsis

Abstract

Cholesterol has been implicated in various neurodegenerative diseases. Here we review the connection between cholesterol and Alzheimer's disease (AD), focusing on a recent study that links neuronal cholesterol esterification with biosynthesis of 24(S)‐hydroxycholesterol and the fate of human amyloid precursor protein in a mouse model of AD. We also briefly evaluate the potential of ACAT1 as a drug target for AD. © 2010 IUBMB IUBMB Life, 62(4): 261–267, 2010