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Neuronal and Glial Expression of the Multidrug Resistance Gene Product in an Experimental Epilepsy Model

✍ Scribed by Alberto Lazarowski; Alberto Javier Ramos; Hernán García-Rivello; Alicia Brusco; Elena Girardi


Book ID
111576695
Publisher
Springer
Year
2004
Tongue
English
Weight
477 KB
Volume
24
Category
Article
ISSN
0272-4340

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P-Glycoprotein (PGP), a product of the multidrug resistance gene (mdr), acts as an adenosine triphosphate-dependent drug efflux system in cells. Initially, PGP was found in cancer cells, but it is now known that PGP is richly distributed in the adult brain. Passage to the central nervous system is l