Neuromuscular dysfunction in the mutant superoxide dismutase mouse model of amyotrophic lateral sclerosis
β Scribed by Parkhouse, Wade S.; Cunningham, Lori; McFee, Ingrid; Litt Miller, Jennifer M.; Whitney, Darryl; Pelech, Steven L.; Krieger, Charles
- Book ID
- 120389661
- Publisher
- Informa plc
- Year
- 2008
- Tongue
- English
- Weight
- 733 KB
- Volume
- 9
- Category
- Article
- ISSN
- 1471-180X
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π SIMILAR VOLUMES
Amyotrophic lateral sclerosis (ALS) is a devastating neurologic disease characterized by progressive motor dysfunction that leads to paralysis and eventually death. There are numerous hypotheses for the pathogenesis of this disease, but the mechanisms of degeneration were difficult to investigate be
## Abstract High molecular weight detergentβinsoluble complexes of superoxide dismutase 1 (SOD1) enzyme are a biochemical abnormality associated with mutant SOD1βlinked familial amyotrophic lateral sclerosis (FALS). In the present study, SOD1 protein from spinal cords of transgenic FALS mice was fr