✦ LIBER ✦

Neuromuscular blocking properties of lincomycin

✍ Scribed by Robert N. Straw; Jerry B. Hook; Harold E. Williamson; C. L. Mitchell

Publisher: John Wiley and Sons
Year: 1965
Tongue: English
Weight: 123 KB
Volume: 54
Category: Article
ISSN: 0022-3549
DOI: 10.1002/jps.2600541228

No coin nor oath required. For personal study only.

✦ Synopsis

Theintravenous injeaionoflincomycin (12.5, 2 5 , and 50 mg./Kg.) into rabbits produced a dose-related neuromuscular blockade. This blockade was not reversed by the injection of neostigmine methylsulfate.

J / cent

Fig. blockade 1.-Plot vs. of dose per (log scale). Three animals were used in a Latin square design. Slope of line = 45.6.

REVIOUS investigators have reported that cer-P tain antibiotics possess neuromuscular blocking properties. Among these are neomycin ( l ) , streptomycin (2), paromomycin (3), colistin (4), kanamycin, dihydrostreptomycin, and polymixin B (5). Thus, it was of interest to evaluate a new antibiotic, lincomycin, with respect to its potential as a neuromuscular blocking agent.

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