## Abstract Alzheimer's disease (AD) and prion disease are characterized neuropathologically by extracellular deposits of Aβ and PrP amyloid fibrils, respectively. In both disorders, these cerebral amyloid deposits are co‐localized with a broad variety of inflammation‐related proteins (complement f
Neuroinflammation in Huntington’s disease
✍ Scribed by Thomas Möller
- Publisher
- Springer
- Year
- 2010
- Tongue
- English
- Weight
- 230 KB
- Volume
- 117
- Category
- Article
- ISSN
- 1435-1463
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Huntington's disease (HD) is a late-onset degenerative disorder of the central nervous system, caused by a dominantly inherited mutation in a gene on chromosome 4p. The identification of the trinucleotide repeat mutation responsible for this disorder has been an important step towards understanding
## Abstract The authors report a patient with Huntington's disease (HD) presenting with severe chorea. The motor scale of the unified HD rating scale (UHDRS‐I) revealed 81 points. Motor function clearly improved with zotepine, until she reached an UHDRS‐I of 34 points on day 7 of treatment. The pat
## Abstract Motor activity was quantitatively assessed over a period of 5 days using a wrist‐worn activity monitor in 14 patients with Huntington's disease (of whom 4 used neuroleptic drugs) and 14 age and sex‐matched healthy controls. Additionally, patients were rated for dementia, depression, cli