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Zotepine in Huntington's disease

✍ Scribed by Raphael M. Bonelli; Gerald Niederwieser; Theresa Lahousen; Peter Hofmann

Publisher: John Wiley and Sons
Year: 2003
Tongue: English
Weight: 72 KB
Volume: 18
Category: Article
ISSN: 0885-6222
DOI: 10.1002/hup.474

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✦ Synopsis

Abstract

The authors report a patient with Huntington's disease (HD) presenting with severe chorea. The motor scale of the unified HD rating scale (UHDRS‐I) revealed 81 points. Motor function clearly improved with zotepine, until she reached an UHDRS‐I of 34 points on day 7 of treatment. The patient was stable for at least 12 weeks. The improvement includes all seven categories of the UHDRS‐I, especially chorea, gait and oral function. This is the first description of zotepine in HD. Our findings suggest that zotepine is useful in the treatment of HD chorea. Controlled trials of its use in HD would be welcome. Copyright © 2003 John Wiley & Sons, Ltd.

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