Neuroimaging Genetics: Principles and Practices

✍ Scribed by Kristin L. Bigos, Ahmad R. Hariri, Daniel R. Weinberger

• Publisher: Oxford University Press
• Year: 2016
• Tongue: English
• Leaves: 433
• Edition: 1st
• Category: Library

✦ Synopsis

Outlines the basic principles of neuroimaging techniques
Focuses on the application of imaging genetics for understanding neurochemical systems and pathways in the brain
Provides examples of imaging genetics research into psychiatric and neurologic illness as well as behavior and personality

The field of neuroimaging genetics has grown exponentially over the past decade. To date there are more than 10,000 published papers involving MRI, PET, MEG and genetics.

Neuroimaging Genetics: Principles and Practices is the comprehensive volume edited by Drs. Bigos, Hariri, and Weinberger and co-authored by the preeminent scholars in the field. This text reviews the basic principles of neuroimaging techniques and their application to neuroimaging genetics.

The work presented in this volume elaborates on the explosive interest from diverse research areas in psychiatry and neurology in the use of imaging genetics as a unique tool to establish and identify mechanisms of risk, establish biological significance, and extend statistical evidence of genetic associations. Examples throughout highlight the application of imaging genetics to understand neurochemical systems and pathways, explore relationships between genetics and the structural and functional connectivity in human brain, and provide insight into mechanisms of risk for psychiatric and neurologic illness.

REVIEW

"Neuroimaging Genetics: Principles and Practice edited by Bigos, Hariri and Weinberger is the first volume in the field devoted to this burgeoning area of research. It brings together many of the pioneering investigators in the field who collectively summarize the history and current state of the art... [and] includes both chapters on specific neurochemically defined circuits including serotonin and dopamine, as well as those that are more disease specific, e.g schizophrenia, Williams syndrome, anxiety disorders and bipolar disorder. ... For the interdisciplinary investigator/student at the interface of genetics, neuroradiology, psychiatry, and neurology, this will be an enjoyable, informative read." --Charles B. Nemeroff, MD, PhD, Leonard M. Miller Professor and Chairman, Department of Psychiatry and Behavioral Sciences, Director, Center on Aging, Leonard M. Miller School of Medicine, University of Miami, FL

"In the few years since this method was initially conceived, imaging genetics has emerged as a valuable tool to understand mechanisms of psychiatric disease, understanding how genes work on the level of brain, and to guide the search for new treatments. ... Scholarly and practical at the same time, this book will be an asset to the library of researchers in psychiatry, neuroscience, and genetics, as well as for practitioners curious where the research frontier now lies." --Andreas Meyer-Lindenberg, MD, Director and CEO, Central Institute of Mental Health, Mannheim; and Chair of Psychiatry and Psychotherapy, University of Heidelberg / Medical Faculty Mannheim, Germany

✦ Table of Contents

Cover......Page 1
Neuroimaging Genetics......Page 4
Copyright......Page 5
Contents......Page 6
Contributors......Page 8
1. Neuroimaging Genetics......Page 12
Part I. Imaging Genetics and Neurochemistry......Page 24
2. Molecular Neuroimaging Genetics......Page 26
3. Neuroreceptor Imaging of Genetic Variation
Impacting the Serotonin Transporter......Page 42
4. Imaging of Genetic Variation Impacting Dopamine Transmission Parameters......Page 60
5. Imaging Genetics of Dopamine Synaptic
Terminal Activity......Page 78
Part II. Imaging Genetics and Drug Discovery......Page 90
6. Variability of Antidepressant Drug Response:
Contribution of Imaging Genetics Studies......Page 92
7. Imaging Genetics of Pharmacological
Response in Psychiatric Disorders......Page 112
Part III. Imaging Genetics and Genetic Discovery......Page 122
8. Imaging Genetics of Williams Syndrome......Page 124
9. Identifying Unanticipated Genes and
Mechanisms in Serious Mental Illness:
GWAS-Based Imaging Genetics Strategies......Page 152
10. Genetics of Brain Structure......Page 168
11. Imaging Genetics of Reward Processing
in the Human Brain......Page 178
Part IV. Imaging Genetics and Disease......Page 196
12. Imaging Genetics of Schizophrenia......Page 198
13. Imaging Genetics of Depression......Page 220
14. Imaging Genetics of Anxiety Disorders......Page 234
15. Imaging Genetics of Bipolar Disorder......Page 244
16. Genetic Neuroimaging Studies of Basal
Ganglia Disorders......Page 252
17. Imaging Genetics of Antisocial Behavior
and Psychopathy......Page 262
Part V. Imaging Genetics and the Environment......Page 276
18. Incorporating the Environment into
Neurogenetics Research: An Imaging
Gene by Environment Interactions
(IG x E) Approach......Page 278
Part VI. Imaging Genetics and Cognition......Page 298
19. Imaging Genetics of Episodic Memory......Page 300
20. Imaging Genetics of Working Memory......Page 320
Part VII. Imaging Genetics of Cognitive Aging......Page 336
21. Neurobiology and Genetics of Cognitive Aging: Insights from Neuroimaging Studies......Page 338
22. Neuroimaging Genetics of Alzheimer’s Disease......Page 368
Part VIII. Imaging Genetics and Multi-Locus Models......Page 406
23. Imaging Genetics of the Hypothalamic-
Pituitary-Adrenal Axis: Implications for
Psychopathology......Page 408
Index......Page 422

✦ Subjects

Genetics; Neuroscience; Psychiatry and Behavioral Sciences; Neuroimaging