Cardiovascular Genetics and Genomics: Principles and Clinical Practice

✍ Scribed by Dhavendra Kumar,Perry Elliott (eds.)

• Publisher: Springer International Publishing
• Year: 2018
• Tongue: English
• Leaves: 921
• Edition: 1
• Category: Library

✦ Synopsis

This title reflects the exponential growth in the knowledge and information on this subject and defines the extensive clinical translation of cardiovascular genetics and genomics in clinical practice. This concise, clinically oriented text is targeted at a broad range of clinicians who manage patients and families with a wide range of heterogeneous inherited cardiovascular conditions.

Cardiovascular Genetics and Genomics: Principles and Clinical Practice includes a concise and clear account on selected topics written by a team of leading experts on clinical cardiovascular genetics. Each chapter include key information to assist the clinician and case histories have been incorporated to reflect contemporary practice in clinical cardiovascular genetics and genomics. Therefore this will be of key importance to all professionals working in the discipline, from clinicians and trainees in cardiology, cardiac surgery, electrophysiology, immunology through geneticists, nursing staff and those involved in precision medicine.

✦ Table of Contents

Front Matter ....Pages i-xix
Introduction to Genes, Genome and Inheritance (Dhavendra Kumar)....Pages 1-34
Spectrum and Classification of Inherited Cardiovascular Disease (Paul Brennan)....Pages 35-69
Principles and Practice of Genetic Counselling for Inherited Cardiac Conditions (Sharon Jenkins, Caroline Kirwan)....Pages 71-95
Genetic and Genomic Technologies: Next Generation Sequencing for Inherited Cardiovascular Conditions (Lorenzo Monserrat)....Pages 97-117
Pharmacogenetics and Pharmacogenomics in Cardiovascular Medicine and Surgery (Richard Myles Turner, Sir Munir Pirmohamed)....Pages 119-172
Congenital Cardiovascular Disorders (Dirk G. Wilson)....Pages 173-188
Inherited Cardiovascular Metabolic Disorders (Elaine Murphy, Oliver Watkinson)....Pages 189-237
Mitochondrial Cardiovascular Diseases (Michael J. Keogh, Hannah E. Steele, Patrick F. Chinnery)....Pages 239-258
Inherited Cardiac Muscle Disorders: Hypertrophic and Restrictive Cardiomyopathies (Mohammed Majid Akhtar, Juan Pablo Kaski, Perry Elliott)....Pages 259-317
Inherited Cardiac Muscle Disease: Dilated Cardiomyopathy (Eloisa Arbustini, Lorenzo Giuliani, Alessandro Di Toro, Valentina Favalli)....Pages 319-366
Inherited Cardiac Muscle Disorders: Arrhythmogenic Right Ventricular Cardiomyopathy (Kalliopi Pilichou, Barbara Bauce, Gaetano Thiene, Cristina Basso)....Pages 367-388
Inherited Cardiac Muscle Disorders: Left Ventricular Noncompaction (James Marangou, Michael Frenneaux, Girish Dwivedi)....Pages 389-412
Inherited Arrhythmias: LQTS/SQTS/CPVT (Andrea Mazzanti, Silvia G. Priori)....Pages 413-435
Inherited Arrhythmias: Brugada Syndrome and Early Repolarisation Syndrome (Pieter G. Postema, Krystien V. V. Lieve, Arthur A. M. Wilde)....Pages 437-480
Inherited Conduction Disease and Atrial Fibrillation (Claire Martin, Pier Lambiase)....Pages 481-522
Cardiovascular Manifestations in Duchenne/Becker Muscular Dystrophy and Other Primary Myopathies (Douglas A. Stoller, Pradeep P. A. Mammen)....Pages 523-543
Familial Cardiac Amyloidoses (Claudio Rapezzi, Christian Gagliardi, Fabrizio Salvi, Ilaria Bartolomei, Candida Cristina Quarta, Agnese Milandri)....Pages 545-577
Cardiovascular Manifestations of Myotonic Dystrophy (Umesh Vivekananda, Michael Hanna, Chris Turner)....Pages 579-587
Marfan Syndrome and Related Disorders (John C. S. Dean, Bart Loeys)....Pages 589-615
Cardiovascular Manifestations in Inherited Connective Tissue Disorders (Julie de Backer, Anne de Paepe)....Pages 617-646
Thoracic Aortic Dilatation, Aneurysm and Dissection (Michael Ibrahim, Nimesh D. Desai)....Pages 647-660
Genetics and Genomics of Coronary Artery Disease (Yoshiji Yamada, Yoshiki Yasukochi)....Pages 661-678
Cardiovascular Manifestations of Immune-Mediated Inflammatory Disorders (Anna Abou-Raya, Suzan Abou-Raya)....Pages 679-693
Genetics and Genomics of Stroke (Rhea Y. Y. Tan, Hugh S. Markus)....Pages 695-722
Genetics and Genomics of Systemic Hypertension (Patricia B. Munroe, Syeda N. S. Jahangir, Mark J. Caulfield)....Pages 723-740
Inherited Pulmonary Arterial Hypertension (Sophie Herbert, Robert M. R. Tulloh)....Pages 741-753
Genetics and Genomics of Sudden Unexplained Cardiac Death (Efstathios Papatheodorou, Mary N. Sheppard, Elijah R. Behr)....Pages 755-779
Specific Issues in Clinical Genetics and Genetic Counselling Practices Related to Inherited Cardiovascular Conditions (Angus Clarke, Siv Fokstuen)....Pages 781-815
Multi-Disciplinary Management of Inherited Cardiovascular Conditions (Gerry Carr-White, Robert Leema)....Pages 817-838
Interventions and Implantable Devices for Inherited Cardiac Conditions (Zaheer Yousef, Mark Drury-Smith)....Pages 839-867
Inherited Cardiovascular Conditions: Phenotype-Genotype Data Mining and Sharing, and Databases (J. Peter van Tintelen, Paul A. van der Zwaag)....Pages 869-877
Back Matter ....Pages 879-920

✦ Subjects

Cardiology