Neurogenic influences of bilateral adrenalectomy on monoamine oxidase

✍ Scribed by David E. Clarke; Sumathy S. Sampath

• Publisher: John Wiley and Sons
• Year: 1976
• Tongue: English
• Weight: 478 KB
• Volume: 65
• Category: Article
• ISSN: 0022-3549
• DOI: 10.1002/jps.2600650119

✦ Synopsis

0 Bilateral adrenalectomy (10 days) increased the amine oxidase was reduced markedly by 6-hydroxydopamine, but monoamine oxidase activity of the rat heart, vas deferens, spleen, the remaining activity was still significantly elevated over the resuperior cervical ganglion, and hypothalamus but not that of the spective control values. The data suggest that the increase in organ rest of the brain, kidney, and liver. Experiments were made to de-monoamine oxidase is predominantly of neuronal origin and that termine whether the increased activitv was due to neuroeenic in-this increase is not due to transsvnaotic induction. fluences and whether the enhanced activity of monoamine oxidase was intra-or extraneuronally located. Ganglionic blockade with chlorisondamine failed to alter the rise in cardiac monoamine oxidase. Likewise, superior cervical ganglion monoamine oxidase was unaffected by surgical denervation. 6-Hydroxydopamine abolished the increase in monoamine oxidase activity of the vas deferens, spleen, and superior cervical ganglion but failed to alter that of the kidney, hypothalamus, and the rest of the brain. Cardiac mono-Keyphrases Monoamine oxidase-activity, effect of bilateral adrenalectomy, 6-hydroxydopamine, chlorisondamine, rat organs 6-Hydroxydopamine-effect on monoamine oxidase activity after bilateral adrenalectomy, rat organs 0 Chlorisondamine-effect on monoamine oxidase activity after bilateral adrenalectomy, rat organs 0 Adrenalectomy, bilateral-effect on monoamine oxidase activity, rat organs