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Neurofibromatosis type 1 peripheral nerve tumors: aberrant activation of the ras pathway

โœ Scribed by Matthias M Feldkamp; Lilyana Angelov; Abhijit Guha

Book ID
117262127
Publisher
Elsevier Science
Year
1999
Tongue
English
Weight
429 KB
Volume
51
Category
Article
ISSN
0090-3019

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The two main peripheral nerve sheath tumors found in patients with neurofibromatosis, type 1 (NF1), are neurofibroma, a benign tumor, and malignant peripheral nerve sheath tumor (MPNST). The tumors are related in that most MPNSTs are thought to arise by malignant transformation of neurofibromas. Suc

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## Abstract Telomerase activity (TA) and the expression of its enzymatic subunits, which have been demonstrated in many tumors, remain poorly investigated in tumors associated with neurofibromatosis type 1 (NF1). In this study, we analysed the association of TA and the expression of telomerase RNA