Serum biomarkers for neurofibromatosis type 1 and early detection of malignant peripheral nerve-sheath tumors
✍ Scribed by Su-Jin Park, Birgit Sawitzki, Lan Kluwe, Victor F Mautner, Nikola Holtkamp…
- Book ID
- 120683916
- Publisher
- BioMed Central
- Year
- 2013
- Tongue
- English
- Weight
- 350 KB
- Volume
- 11
- Category
- Article
- ISSN
- 1741-7015
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## Abstract Telomerase activity (TA) and the expression of its enzymatic subunits, which have been demonstrated in many tumors, remain poorly investigated in tumors associated with neurofibromatosis type 1 (NF1). In this study, we analysed the association of TA and the expression of telomerase RNA
The two main peripheral nerve sheath tumors found in patients with neurofibromatosis, type 1 (NF1), are neurofibroma, a benign tumor, and malignant peripheral nerve sheath tumor (MPNST). The tumors are related in that most MPNSTs are thought to arise by malignant transformation of neurofibromas. Suc