𝔖 Bobbio Scriptorium
✦   LIBER   ✦

Neurochemical effects of cocaine following acute and repeated injection

✍ Scribed by Dorothy Taylor; Dr. Beng T. Ho

Book ID
102385624
Publisher
John Wiley and Sons
Year
1977
Tongue
English
Weight
406 KB
Volume
3
Category
Article
ISSN
0360-4012

No coin nor oath required. For personal study only.

✦ Synopsis

Abstract

Following repeated injection in the rat, cocaine decreased the concentration of serotonin in the septum‐caudate and increased the metabolism of hypothalamic norepinephrine and also striatal dopamine to a lesser extent. Furthermore, cocaine significantly decreased the activity of the rate‐limiting enzyme, tryptophan hydroxylase. In a comparative study d‐amphetamine and methylphenidate were found to exert an effect opposite to cocaine in the activation of tryptophan hydroxylase. These findings indicate that cocaine may lower central serotonin function by decreasing its availability for neural transmission. This count account for the stimulation of locomotor activity observed after cocaine administration.

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