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Neurobiological mechanisms in the transition from drug use to drug dependence

✍ Scribed by George F Koob; Serge H Ahmed; Benjamin Boutrel; Scott A Chen; Paul J Kenny; Athina Markou; Laura E O'Dell; Loren H Parsons; Pietro Paolo Sanna

Publisher
Elsevier Science
Year
2004
Tongue
English
Weight
466 KB
Volume
27
Category
Article
ISSN
0149-7634

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## Abstract ## Rationale Serotonergic (5‐HT) mechanisms appear to mediate central effects of cocaine. Therefore 5‐HT disturbances could be associated with drug severity. ## Objectives We investigated whether prolactin (PRL) response to meta‐chlorophenylpiperazine (m‐CPP), a mixed 5‐HT agonist/an