Neural tube defects and disturbed maternal folate- and homocysteine-mediated one-carbon metabolism
β Scribed by Hong-Yang Zhang; Guo-An Luo; Qiong-Lin Liang; Yong Wang; Hui-Hua Yang; Yi-Ming Wang; Xiao-Ying Zheng; Xin-Ming Song; Gong Chen; Ting Zhang; Jian-Xin Wu
- Book ID
- 116459359
- Publisher
- Elsevier Science
- Year
- 2008
- Tongue
- English
- Weight
- 535 KB
- Volume
- 212
- Category
- Article
- ISSN
- 0014-4886
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## Abstract ## BACKGROUND Alterations in maternal folate and homocysteine metabolism are associated with neural tube defects (NTDs). The role played by specific micronutrients and metabolites in the causal pathway leading to NTDs is not fully understood. ## METHODS We conducted a caseβcontrol st
## Abstract ## BACKGROUND Neural tube defects (NTDs) are among the most common severe congenital malformations, representing a longβterm public health burden in India. A deranged oneβcarbon metabolism and genes regulating this metabolism have been linked to NTDs. Vitamin B~12~ deficiency is report