Folate-mediated one-carbon metabolism and neural tube defects: Balancing genome synthesis and gene expression

Neural tube defects induced by folate de

Neural tube defects induced by folate deficiency in mutant curly tail (Grhl3) embryos are associated with alteration in folate one-carbon metabolism but are unlikely to result from diminished methylation

✍ Sandra C. P. De Castro; Kit-yi Leung; Dawn Savery; Katie Burren; Rima Rozen; And 📂 Article 📅 2010 🏛 John Wiley and Sons 🌐 English ⚖ 196 KB 👁 1 views

## Abstract **BACKGROUND:** Folate one‐carbon metabolism has been implicated as a determinant of susceptibility to neural tube defects (NTDs), owing to the preventive effect of maternal folic acid supplementation and the higher risk associated with markers of diminished folate status. **METHODS:**