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Neural crest-derived stem cells display a wide variety of characteristics

✍ Scribed by Narihito Nagoshi; Shinsuke Shibata; Masaya Nakamura; Yumi Matsuzaki; Yoshiaki Toyama; Hideyuki Okano

Publisher
John Wiley and Sons
Year
2009
Tongue
English
Weight
144 KB
Volume
107
Category
Article
ISSN
0730-2312

No coin nor oath required. For personal study only.

✦ Synopsis

Abstract

A recent burst of findings has shown that neural crest‐derived stem cells (NCSCs) can be found in diverse mammalian tissues. In addition to their identification in tissues that are known to be derived from the neural crest, recent studies have revealed NCSCs in tissues that are not specifically derived from the neural crest, such as bone marrow. NCSCs can express a wide range of characteristics, and which properties are expressed mainly depends on their tissue sources and the ontogenic stage of the animal. The identification of NCSCs in various tissues opens an entirely new avenue of approach to developing autologous cell replacement therapies for use in regenerative medicine. In this review, we discuss the origin, migration, and lineage potential of NCSCs from various mammalian tissue sources. J. Cell. Biochem. 107: 1046–1052, 2009. © 2009 Wiley‐Liss, Inc.

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