Background: In vertebrate embryos, migration of trunk neural crest cells (NCC) proceeds mainly in two streams: a dorsoventral path between the neural tube and somites, and a dorsolateral one between somites and ectoderm. This last pathway is taken by melanocyte precursor cells (MPC) homing the skin,
Induction and patterning of the neural crest, a stem cell-like precursor population
โ Scribed by LaBonne, Carole ;Bronner-Fraser, Marianne
- Publisher
- John Wiley and Sons
- Year
- 1998
- Tongue
- English
- Weight
- 348 KB
- Volume
- 36
- Category
- Article
- ISSN
- 0022-3034
No coin nor oath required. For personal study only.
โฆ Synopsis
The neural crest is a multipotent precursor population which ultimately generates much of the peripheral nervous system, epidermal pigment cells, and a variety of mesectodermal derivatives. Individual multipotent neural crest cells are capable of some self-renewing divisions, and based upon this criteria can be considered stem cells. Considerable progress has been made in recent years toward understanding how this important population of progenitor cells is initially established in the early embryo, and how cell-intrinsic and non-cell-intrinsic factors mediate their subsequent lineage segregation and differentiation.
๐ SIMILAR VOLUMES
Combined sialyltransferase (ST) activities were induced in the HN9 hippocampal cell line following treatment with the synthetic glucocorticoid dexamethasone (dex) for 24 hr. Induction occurred in a dosedependent manner, with the maximum induction of a 2-fold increase over control enzyme levels occur
Background: Osteopontin previously has been shown to be expressed in the early notochord and rostral hindbrain during formation of the rat neuraxis. Both of these sites are known to have important organizing capacities associated with the expression of a number of transcription factors and secreted
A melanin-associated agent seems to play a role in regulating retinal development. When absent, diverse deficits occur. There is evidence that this agent regulates patterns of mitosis. This study examines retinal development in pigmented and albino rats to identify the regulating agent and its mode