Mutational activation of cellular proto-oncogenes is an important event in the pathogenesis of chemically induced tumors. We have used the ori P-tk shuttle vector, pHET, to analyze the types o f DNA sequence changes induced after treating mammalian cells with the carcinogen N-ethyl-N-nitrosourea (EN
β¦ LIBER β¦
neu Mutations and loss of normal allele in schwannomas induced by N-ethyl-N-nitrosourea in rats
β Scribed by Ohgaki, H.; Vogeley, K.T.; Kleihues, P.; Wechsler, W.
- Book ID
- 122974803
- Publisher
- Elsevier Science
- Year
- 1993
- Tongue
- English
- Weight
- 578 KB
- Volume
- 70
- Category
- Article
- ISSN
- 0304-3835
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## Abstract In our previous study (Wang __et al.__, 2004, __Toxicol. Sci.__ 82: 124β128), we observed that the __cII__ gene mutant frequency (MF) in the bone marrow of Big Blue mice showed significant increase as early as day 1, reached the maximum at day 3 and then decreased to a plateau by day 15