Mutational activation of cellular proto-oncogenes is an important event in the pathogenesis of chemically induced tumors. We have used the ori P-tk shuttle vector, pHET, to analyze the types o f DNA sequence changes induced after treating mammalian cells with the carcinogen N-ethyl-N-nitrosourea (EN
Molecular analysis of mutations induced by N-ethyl-N-nitrosourea at the HPRT locus in mouse lymphoma cells
โ Scribed by H. Vrieling; M.J. Niericker; J.W.I.M. Simons; A.A. van Zeeland
- Book ID
- 113193384
- Publisher
- Elsevier Science
- Year
- 1988
- Tongue
- English
- Weight
- 616 KB
- Volume
- 198
- Category
- Article
- ISSN
- 0027-5107
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## Abstract In our previous study (Wang __et al.__, 2004, __Toxicol. Sci.__ 82: 124โ128), we observed that the __cII__ gene mutant frequency (MF) in the bone marrow of Big Blue mice showed significant increase as early as day 1, reached the maximum at day 3 and then decreased to a plateau by day 15