The endogenous, autosomal Tk gene is a potentially useful reporter of in vivo mutation since it may recover a wider range of mutational events than the X-linked Hprt gene or bacterial transgenes. In this study, we characterized mutations produced in the Tk gene of Tk ฯฉ/ฯช mice and compared them with
โฆ LIBER โฆ
Mutant frequency and mutational spectra in the Tk and Hprt genes of N-ethyl-N-nitrosourea-treated mouse lymphoma cells
โ Scribed by Tao Chen; Karen Harrington-Brock; Martha M. Moore
- Publisher
- John Wiley and Sons
- Year
- 2002
- Tongue
- English
- Weight
- 119 KB
- Volume
- 39
- Category
- Article
- ISSN
- 0893-6692
- DOI
- 10.1002/em.10075
No coin nor oath required. For personal study only.
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The newborn mouse tumorigenicity assay, which reached 155.1 1 10 06 following a cumulative dose involves the treatment of animals during the first two of 49 mg ENU/kg body weight and 172.3 1 10 06 weeks after birth and monitoring tumor induction following a cumulative dose of 142 mg ENU/kg. after a