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Nerve growth factor regulation of choline acetyltransferase gene expression in rat embryo basal forebrain cultures

✍ Scribed by Lorenzi, Matthew V.; Knusel, Beat; Hefti, Franz; Strauss, William L.

Book ID: 123353453
Publisher: Elsevier Science
Year: 1992
Tongue: English
Weight: 438 KB
Volume: 140
Category: Article
ISSN: 0304-3940
DOI: 10.1016/0304-3940(92)90098-R

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Nerve growth factor (NGF) is a potential treatment for cholinergic dysfunction associated with Alzheimer's disease (AD). In rats, NGF activates gene expression of the acetylcholine synthetic enzyme choline acetyltransferase (ChAT) and prevents age-and lesion-induced degeneration of basal forebrain (