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Nerve growth factor induces trkA mRNA expression in cultured basal forebrain cholinergic neurons from 17-day fetal rats

✍ Scribed by Kojima, Masami; Ikeuchi, Toshihiko; Hatanaka, Hiroshi

Book ID: 122959465
Publisher: Elsevier Science
Year: 1994
Tongue: English
Weight: 679 KB
Volume: 169
Category: Article
ISSN: 0304-3940
DOI: 10.1016/0304-3940(94)90353-0

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Nerve growth factor (NGF) is a potential treatment for cholinergic dysfunction associated with Alzheimer's disease (AD). In rats, NGF activates gene expression of the acetylcholine synthetic enzyme choline acetyltransferase (ChAT) and prevents age-and lesion-induced degeneration of basal forebrain (