## Abstract Glucocorticoids and nerve growth factor (NGF) have been shown to have antagonistic effects on chromaffin cells in vivo. Here we determined the effect of the synthetic glucocorticoid, dexamethasone, on levels of mRNA for the nerve growth factor receptor (NGFR) in rat PC12 pheochromocytom
Nerve growth factor mediates activation of the Smad pathway in PC12 cells
โ Scribed by Marion Lutz; Kerstin Krieglstein; Simone Schmitt; Peter ten Dijke; Walter Sebald; Andrea Wizenmann; Petra Knaus
- Book ID
- 110914930
- Publisher
- John Wiley and Sons
- Year
- 2004
- Tongue
- English
- Weight
- 591 KB
- Volume
- 271
- Category
- Article
- ISSN
- 1432-1327
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## Abstract In 1999, we reported new observations that several compounds, including ATP, enhance neurite expression in PC12 cells when coapplied with nerve growth factor (NGF). Because purinergic and NGF signaling have several potential interfaces in PC12 cells, a series of experiments was conducte
Treatment of PC12 cells with nerve growth factor (NGF) produces a rapid and transient increase in calcium uptake into the cells. The increased uptake is maximal after 5 minutes of NGF treatment, but after 15 minutes of NGF treatment, no such increase can be observed. The effect of NGF is partially i