✦ LIBER ✦

Nerve growth factor: a neurotrophin with activity on cells of the immune system

✍ Scribed by Aloe, L.; Simone, M.D.; Properzi, F.

Publisher: John Wiley and Sons
Year: 1999
Tongue: English
Weight: 85 KB
Volume: 45
Category: Article
ISSN: 1059-910X
DOI: 10.1002/(sici)1097-0029(19990515/01)45:4/5<285::aid-jemt12>3.0.co;2-3

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✦ Synopsis

Numerous studies published in the last two decades provide evidence that nerve growth factor (NGF), a polypeptide originally discovered because of its neurotrophic activity, acts on a variety of cells of the immune system, including mast cells, eosinophils, and B and T lymphocytes. NGF has been shown to increase during inflammatory responses, autoimmune disorders, parasitic infections, and allergic diseases. Moreover, stress, which is characterized also by activation of a variety of immune cells, causes a significant increase in basal plasma NGF levels. Recently published studies reveal that hematopoietic progenitor cells seem to be able to produce and/or respond to NGF. We report these data and discuss the hypothesis of the possible implication of NGF on the functional activities of immune cells. Microsc.

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