Nerve conduction abnormalities in the trembler-j mouse: A model for Charcot-Marie-Tooth disease type 1A?
β Scribed by Gregg D. Meekins; Michael J. Emery; Michael D. Weiss
- Book ID
- 110760860
- Publisher
- John Wiley and Sons
- Year
- 2004
- Tongue
- English
- Weight
- 212 KB
- Volume
- 9
- Category
- Article
- ISSN
- 1085-9489
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## Abstract Expression profiling was performed on sciatic nerve of normal mice and of transgenic mice overexpressing the peripheral myelin protein 22 kDa (PMP22). These mice represent a model for the hereditary peripheral neuropathy CharcotβMarie Tooth type 1A. Comparison of the profiles reveals th
Peripheral myelin protein-22 (PMP22) is expressed in myelinating Schwann cells and shows significant homology to murine growth arrest-specific gene gas3. Charcot-Marie-Tooth disease type l a (CMTla) is a common hereditary demyelinating neuropathy. Recently it was demonstrated that the gene for PMP22