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Nerve allografts supplemented with schwann cells overexpressing glial-cell-line-derived neurotrophic factor

✍ Scribed by Santosa, Katherine B.; Jesuraj, Nithya J.; Viader, Andreu; MacEwan, Matthew; Newton, Piyaraj; Hunter, Daniel A.; Mackinnon, Susan E.; Johnson, Philip J.

Book ID
118764847
Publisher
John Wiley and Sons
Year
2012
Tongue
English
Weight
838 KB
Volume
47
Category
Article
ISSN
0148-639X

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Glial cell line-derived neurotrophic factor (GDNF) was first discovered as a potent survival factor for midbrain dopaminergic neurons and was then shown to rescue these neurons in animal models of Parkinson's disease. GDNF is a more potent survival factor for dopaminergic neurons and the noradrenerg