Background. Vitamin B12 assay is part of the routine investigation of dementia, although few studies have investigated the eects of treatment on cognition. We examined the eects of B12 treatment on neuropsychological function and disease progression in patients presenting with dementia or cognitive
Neprilysin Deficiency-Dependent Impairment of Cognitive Functions in a Mouse Model of Amyloidosis
โ Scribed by M. Hasan Mohajeri; David P. Wolfer
- Publisher
- Springer
- Year
- 2009
- Tongue
- English
- Weight
- 447 KB
- Volume
- 34
- Category
- Article
- ISSN
- 0364-3190
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Figure 1 Comparison of peak fall in MAP (relative to baseline; A) and 12 hour vehicle adjusted AUC MAP (B) following oral administration of AHU-377 (30 and100 mg/kg, PO) in conscious Dahl-SS and DOCA-salt hypertensive rats (n=4-7 per treatment group).
โฃ-1-Antitrypsin (โฃ1-AT) deficiency is the most common cause of metabolic pediatric liver disease. Hepatocellular injury is caused by toxicity of the mutant โฃ-1-antitrypsin Z (โฃ1-ATZ) molecule retained within hepatocytes. In these studies, we used the PiZ transgenic mouse model of โฃ1-AT deficiency to