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Nephrotoxicity and hepatotoxicity of 1,1-dichloro-2,2-difluoroethylene in the rat: Indications for differential mechanisms of bioactivation

✍ Scribed by J.N.M. Commandeur; R.A.J. Oostendorp; P.R. Schoofs; B. Xu; N.P.E. Vermeulen


Book ID
115779985
Publisher
Elsevier Science
Year
1987
Tongue
English
Weight
1001 KB
Volume
36
Category
Article
ISSN
0006-2952

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## Abstract The role of cytochrome P450 activity in the nephrotoxicity of chlorotrifluoroethylene (CTFE) and 1,1‐dichloro‐2,2‐difluoroethylene (DCDFE) was investigated in the male rat. Hepatic cytochrome P450 1A1 and principally P450 2B1[sol ]2 were induced by __Ξ²__‐naphthoflavone and phenobarbital