NEOPLASTIC TRANSFORMATION OF RAT LIVER EPITHELIAL CELLS IN CULTURE
โ Scribed by R. Montesano; G. Bannikov; C. Drevon; T. Kuroki; L. Saint Vincent; L. Tomatis
- Book ID
- 118718445
- Publisher
- John Wiley and Sons
- Year
- 1980
- Tongue
- English
- Weight
- 908 KB
- Volume
- 349
- Category
- Article
- ISSN
- 0890-6564
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Tumors produced by a chemically transformed rat liver epithelial (RLE) cell line and its single cell-derived clonal subpopulations demonstrate wide-ranging morphological presentations including carcinomas, sarcomas, "mixed epithelial-mesenchymal" tumors, and undifferentiated tumors [Am J Pathol 127:
## Abstract Previous studies demonstrated that hydrogen peroxide (H~2~O~2~) is a tumor promoter in the rat liver epithelial cell line T51B. We investigated the pathway linking H~2~O~2~ to tumor promotion. H~2~O~2~ can directly induce tyrosine phosphorylation of epidermal growth factor receptor (EGF