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Neoadjuvant therapy followed by prostatectomy for clinically localized prostate cancer

✍ Scribed by Guru Sonpavde; Kim N. Chi; Thomas Powles; Christopher J. Sweeney; Noah Hahn; Thomas E. Hutson; Matthew D. Galsky; William R. Berry; Dov Kadmon

Publisher
John Wiley and Sons
Year
2007
Tongue
English
Weight
134 KB
Volume
110
Category
Article
ISSN
0008-543X

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✦ Synopsis

Abstract

The results of this assessment of the literature indicated that neoadjuvant therapy followed by prostatectomy may improve long‐term outcomes for patients with high‐risk localized disease. In addition, this approach provides a paradigm for evaluating the activity and mechanism of action of new agents as correlative studies are facilitated by the availability of tumor tissue before and after therapy. The authors determined that a multidisciplinary approach involving oncologists, urologists, and pathologists is critical to the success of this model. Recent and ongoing studies of neoadjuvant therapy followed by prostatectomy were reviewed. Cancer 2007. © 2007 American Cancer Society.

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