✦ LIBER ✦

Negligible synergistic effect of β2-glycoprotein I on the reactivity of antioxidized low-density lipoprotein antibody to oxidized low-density lipoprotein

✍ Scribed by Matsuda, Juzo; Gotoh, Moritaka; Kawasugi, Kazuo; Gohchi, Kengo; Tsukamoto, Miyo; Saitoh, Noriko

Publisher: John Wiley and Sons
Year: 1996
Tongue: English
Weight: 232 KB
Volume: 52
Category: Article
ISSN: 0361-8609
DOI: 10.1002/(sici)1096-8652(199606)52:2<114::aid-ajh8>3.0.co;2-x

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✦ Synopsis

We conducted this study to investigate whether antioxidized low-density lipoprotein (a-oxLDL) is an antibody to cryptic and/or neo-antigen on p,-glycoprotein I (GPI), which is introduced by binding to anionic phospholipid, similar to that of GPI-dependent anticardiolipin antibody (aCL) employing a-oxLDL ELISA. We found that no significant optical density differences existed among systemic lupus erythematosus patients, including cases with aCL and/or lupus anticoagulant positivity, before and after the addition of GPI. Our results suggest that a-oxLDL is not an antibody to denatured GPI, but rather to OXLDL.

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