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Negative symptoms in Alzheimer's disease: a confirmatory factor analysis

✍ Scribed by Jos F. M. de Jonghe; Arnold W. Goedhart; Marcel E. Ooms; Martin G. Kat; Kees J. Kalisvaart; Wouter M. van Ewijk; Miel W. Ribbe

Publisher
John Wiley and Sons
Year
2003
Tongue
English
Weight
65 KB
Volume
18
Category
Article
ISSN
0885-6230

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✦ Synopsis

Abstract

Objective

To examine different conceptual models of negative symptoms in Alzheimer's disease.

Design

Confirmatory factor analysis of cross‐sectional data.

Subjects

Alzheimer patients (n=281) admitted to a psychogeriatric observation ward.

Materials

Nurses' Behavioural observation scale for psychogeriatric inpatients (GIP). Global clinical ratings of severity of dementia and depression based on the Cambridge Examination for Mental Disorders of the Elderly‐Dutch version (CAMDEX‐N).

Results

A unidimensional model of dementia fitted the data poorly. Multidimensional models produced better results. In two‐ and three‐factor models negative symptoms were separated from cognitive impairment and mood disturbances. The more severe the memory impairment, the more socially withdrawn patients were. In this sense negative symptoms may have been secondary to cognitive decline. However, no association was found between negative symptoms and mood disturbances.

Conclusions

Negative symptoms are a prominent clinical feature of Alzheimer's disease and they are related to memory impairment but not to mood disturbances. Copyright Β© 2003 John Wiley & Sons, Ltd.

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