𝔖 Bobbio Scriptorium
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Negative regulation of T cell receptor signals

✍ Scribed by Manu Rangachari; Josef M Penninger


Book ID
116383255
Publisher
Elsevier Science
Year
2004
Tongue
English
Weight
345 KB
Volume
4
Category
Article
ISSN
1471-4892

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Negative regulation of T cell activation
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T cell activation is negatively regulated by cytotoxic T lymphocyte antigen 4 (CTLA-4) and the killer cell inhibitory receptors. Endocytosis and signaling of CTLA-4 are regulated by tyrosine phosphorylation. While T cell activation is mediated by phosphorylation of immunoreceptor tyrosine-based acti