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Negative regulation of Fc RI-mediated mast cell activation by a ubiquitin-protein ligase Cbl-b

✍ Scribed by Qu, X.

Book ID
121658040
Publisher
American Society of Hematology
Year
2004
Tongue
English
Weight
354 KB
Volume
103
Category
Article
ISSN
0006-4971

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## Abstract **Background:** Recent studies have demonstrated that c‐Cbl functions as a ubiquitin‐protein ligase toward immune receptors and non‐receptor protein‐tyrosine kinase Syk by facilitating their ubiquitination and subsequent targeting to proteasomes. However, it was not clear whether Src fa