Negative naloxone effects in schizophrenic patients

✍ Scribed by David S. Janowsky; David S. Segal; Alan Abrams; Floyd Bloom; Roger Guillemin

• Book ID: 104786441
• Publisher: Springer
• Year: 1977
• Tongue: English
• Weight: 202 KB
• Volume: 53
• Category: Article
• ISSN: 0033-3158
• DOI: 10.1007/bf00492367

✦ Synopsis

On the basis of the hypothesis that the opiate-like neuropeptides, such as beta-endorphin, may be involved in the etiology of schizophrenic symptoms, naloxone 1,2 mg and placebo were administered intravenously to 8 schizophrenic patients, using a double-blind, crossover design. Naloxone was not found to be different from placebo in effecting schizophrenic symptoms, including hallucinations and delusions.