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Negative effect of P72 polymorphism on p53 gene in IVF outcome in patients with repeated implantation failure and pregnancy loss

✍ Scribed by Lledo, Belén; Turienzo, Azahara; Ortiz, Jose A.; Morales, Ruth; Ten, Jorge; Llácer, Joaquin; Bernabeu, Rafael

Book ID
121510399
Publisher
Springer US
Year
2013
Tongue
English
Weight
138 KB
Volume
31
Category
Article
ISSN
1573-7330

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Effect of the codon 72 polymorphism (c.2
Effect of the codon 72 polymorphism (c.215G>C, p.Arg72Pro) in combination with somatic sequence variants in the TP53 gene on survival in patients with advanced ovarian carcinoma
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This study was conducted to evaluate the frequency and prognostic impact of TP53 alterations stratified for the TP53 codon 72 polymorphism (c.215G4C, p.Arg72Pro) in a cohort of 109 patients with advanced ovarian carcinomas. TP53 sequence variants were observed in 80 of the 109 (73.4%) tumors and wer

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The original article to which this Erratum refers was published in Human Mutation 24: 21-34 (2004). Using a newly developed method-Arrayed Primer Extension (APEX) and direct sequencing of exon 10 and 11 to reanalyze for TP53 sequence alterations-13 new mutations were identified. In addition, a few