NEFL-related Charcot–Marie–Tooth disease: An unraveling story

✍ Scribed by Mary M. Reilly

• Publisher: John Wiley and Sons
• Year: 2009
• Tongue: English
• Weight: 46 KB
• Volume: 66
• Category: Article
• ISSN: 0364-5134
• DOI: 10.1002/ana.21848

✦ Synopsis

This novel finding is the first to address androgens in pediatric stroke and is consistent with the rather sparse literature that androgens impact ischemic outcomes and mechanisms of brain damage. 7,[12][13][14][15][16] In contrast, low circulating testosterone levels are associated with higher stroke incidence and worse outcomes after stroke in men. [12][13][14][15][16] Importantly, androgen levels dramatically drop after both experimental and clinical stroke in adults. 14 -16 In experimental studies that control pre-and postischemic androgen levels, androgens can reduce or exacerbate ischemic damage, further confusing the issue. 16,17 In the study by Normann et al, 11 testosterone levels were measured in cases 6 to 12 months after the ischemic event and assumed to reflect prior circulating levels and thus risk. However, regardless of this limitation, it is clear that further clinical and experimental studies are necessary to understand the involvement of circulating androgens in pediatric stroke.