## Abstract Autologous stem cell transplantation (ASCT) has enabled the use of high‐dose alkylating agents either as a single agent or in combination with other cytotoxic agents and/or total body irradiation (TBI) for the treatment of multiple myeloma. Despite improved complete remission rates, rel
Necrosis following skull base irradiation and stem cell transplant for multiple myeloma
✍ Scribed by Sonia Skamene; Ronny L. Rotondo; Chaim Shustik; David Roberge
- Publisher
- John Wiley and Sons
- Year
- 2010
- Tongue
- English
- Weight
- 134 KB
- Volume
- 85
- Category
- Article
- ISSN
- 0361-8609
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## Abstract ## BACKGROUND: Allogeneic stem cell transplantation (SCT) with myeloablative conditioning is potentially curative therapy for myeloma, but is reportedly associated with a high risk of nonrecurrence mortality (NRM). Reduced‐intensity conditioning (RIC) allows for the reduction of NRM, b
## Abstract The recent development of reduced intensity conditioning and allotransplantation (RICT) has opened a new way to assure engraftment of donor cells while reducing early transplant‐related mortality. We evaluated the combination of high‐dose therapy and autologous peripheral blood stem cel