✦ LIBER ✦

Natural resistance against hematopoietic cells in lethally-irradiated mice infected with Friend leukemia virus

✍ Scribed by A. M. Iorio; M. Neri; P. Enrico; F. Titti; G. B. Rossi; E. Bonmassar

Publisher: Springer-Verlag
Year: 1984
Tongue: English
Weight: 685 KB
Volume: 18
Category: Article
ISSN: 0340-7004
DOI: 10.1007/bf00205397

No coin nor oath required. For personal study only.

✦ Synopsis

The influence of in vivo infection with the polycythemic substrain of Friend leukemia virus on noninducible ('natural') resistance against allogeneic normal or malignant grafts was studied in lethally irradiated mice. Parallel studies were performed on the NK system in the same experimental conditions. The results indicate that FLV-P infection of mice with full (DBA/2) vs partial (BALB/c and CD2F1) susceptibility did not suppress their in vivo natural resistance against bone marrow or El-4 leukemia cells. On the other hand, a decline in NK activity paralleled the progression of leukemic disease in the more susceptible DBA/2 hosts.

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