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Expression of Fv-4r allele in hematopoietic cells from g mice resistant to friend leukemia virus

✍ Scribed by Hidetoshi Ikeda; Takeshi Odaka

Publisher
John Wiley and Sons
Year
1979
Tongue
French
Weight
387 KB
Volume
23
Category
Article
ISSN
0020-7136

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✦ Synopsis

Abstract

G mice carrying the Fv‐4 resistant allele supported virus growth neither at an early nor a later (Kai et al., 1976) stage of infection with NB‐tropic FLV. This resistance could not be abolished by treatment of G mice with cyclophosphamide or cortisone acetate. By bone‐marrow or spleen‐cell transplantation into irradiated mice, the resistance of G mice could be transferred to Fv‐4‐susceptible mice. Conversely, transfer of bone‐marrow or spleen cells of Fv‐4‐susceptible mice rendered G mice susceptible. It could be concluded that, as assessed by the virus content in the spleen, helper LLV grows mainly in radiosensitive, bone‐marrow‐derived cells, and the Fv‐4 gene is expressed in these cells.

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