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Natural prevalence of NS5A polymorphisms in subjects infected with hepatitis C virus genotype 3 and their effects on the antiviral activity of NS5A inhibitors

✍ Scribed by Hernandez, Dennis; Zhou, Nannan; Ueland, Joseph; Monikowski, Aaron; McPhee, Fiona

Book ID: 121409872
Publisher: Elsevier Science
Year: 2013
Tongue: English
Weight: 442 KB
Volume: 57
Category: Article
ISSN: 1386-6532
DOI: 10.1016/j.jcv.2012.12.020

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## Abstract Heterogeneity of subgenomic regions of hepatitis C virus (HCV) may be associated with response to interferon (IFN) therapy. The amino acid sequences of the PKR/eIF‐2α phosphorylation homology domain (pePHD), IFN sensitivity determining region (ISDR), PKR binding domain (PKRBD), and vari