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Natural killer (NK) cell immunodeficiency in patients with chronic myelogenous leukemia

✍ Scribed by Yoshiaki Fujimiya; Weng-Cheng Chang; Anthony Bakke; David Horwitz; Paul K. Pattengale


Publisher
Springer-Verlag
Year
1987
Tongue
English
Weight
879 KB
Volume
24
Category
Article
ISSN
0340-7004

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Even though they possess normal to increased numbers of circulating natural killer (NK) cells, patients with chronic myelogenous leukemia (CML) have a functional NK-cell deficiency which is restorable in vitro in the presence of recombinant IL-2. We therefore measured the level of IL-2 production by

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## Abstract Natural killer (NK)^6^ cell activity of peripheral blood lymphocytes against human leukemia cell lines was measured in patients with chronic B‐cell lymphocytic leukemia (CLL) and age‐ and sex‐matched controls. In order to remove the leukemia cells that interfere with the __in vitro__ as