Natural killer cells: Maintaining tolerance
โ Scribed by Bell, Elaine
- Book ID
- 109955080
- Publisher
- Nature Publishing Group
- Year
- 2005
- Tongue
- English
- Weight
- 211 KB
- Volume
- 5
- Category
- Article
- ISSN
- 1474-1741
- DOI
- 10.1038/nri1637
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A natural killer (NK)/l-cell-restricted progenitor cell in the fetal blood, with a phenotype of NKl .l+ CD1 17 (c-kit)+, can give rise to NK cells. IL-1 5 is probably required for NK ceil differentiation and, in addition, stimulates expression of at least one of the MHC-specific inhibitory receptor
Although the antigen-specific receptors of T and B lymphocytes have been characterized, the receptors used by natural killer cells to recognize normal cells, tumors, and virus-infected cells have remained elusive. Recently, experimental systems have been developed to identify these structures, and c