Development and tolerance of natural killer cells

✍ Scribed by David H. Raulet

• Book ID: 104359080
• Publisher: Elsevier Science
• Year: 1999
• Tongue: English
• Weight: 909 KB
• Volume: 11
• Category: Article
• ISSN: 0952-7915
• DOI: 10.1016/s0952-7915(99)80023-5

✦ Synopsis

A natural killer (NK)/l-cell-restricted progenitor cell in the fetal blood, with a phenotype of NKl .l+ CD1 17 (c-kit)+, can give rise to NK cells. IL-1 5 is probably required for NK ceil differentiation and, in addition, stimulates expression of at least one of the MHC-specific inhibitory receptor families expressed by NK cells. Evidence supports the role of multiple mechanisms in rendering NK cells self tolerant -including selection for expression of selfspecific inhibitory receptors, anergy and modulation of the cell surface levels of MHC-specific inhibitory receptors.