In a randomized placebo crossover controlled study, six patients meeting DSM-111-R criteria for Alzheimer's disease and exhibiting significantly aggressive behaviour were administered carbamazepine (in doses up to 600 mg daily) and placebo, with each treatment period lasting 8 weeks. Levels of aggre
Natural history of aggressive behaviour in dementia
โ Scribed by Janet Keene; Tony Hope; Christopher G. Fairburn; Robin Jacoby; Kathy Gedling; Christopher J. G. Ware
- Publisher
- John Wiley and Sons
- Year
- 1999
- Tongue
- English
- Weight
- 104 KB
- Volume
- 14
- Category
- Article
- ISSN
- 0885-6230
No coin nor oath required. For personal study only.
โฆ Synopsis
Objective. This article analyses changes in aggressive behaviour throughout the course of dementia. Design. Prospective, 10 year, longitudinal study of aggressive behaviour in dementia, with autopsy follow-up. Setting. Subjects with dementia, living at home with a carer, Oxfordshire, UK. Participants. Ninety-nine people with dementia (Alzheimer's disease and/or vascular dementia) who were living at home with a carer.
Measures. At 4-monthly intervals, the carers were interviewed about the subjects and the subjects were assessed cognitively. Subjects' behaviour was assessed using the Present Behavioural Examination. This is an investigatorbased, semi-structured interview consisting of eight main sections monitoring behavioural and psychological change. Eight dierent aspects of aggressive behaviour were assessed in detail and comparison made with other relevant factors.
Results. Verbal aggression is the most common and longest lasting form of aggressive behaviour. Aggressive resistance and physical aggression are most likely to persist until death. Intimate care is the main factor precipitating aggressive behaviour. There are no correlations between any type of aggressive behaviour and age, gender or time since onset of dementia.
Conclusions. Aggressive behaviour creates problems for carers. In general, the physical types of aggressive behaviour are most prevalent in people with more severe dementia.
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