✦ LIBER ✦

CARBAMAZEPINE USE IN AGGRESSIVE BEHAVIOUR ASSOCIATED WITH SENILE DEMENTIA

✍ Scribed by COLM COONEY; ANN MORTIMER; ANDREW SMITH; KATE NEWTON; MARGO WRIGLEY

Publisher: John Wiley and Sons
Year: 1996
Tongue: English
Weight: 354 KB
Volume: 11
Category: Article
ISSN: 0885-6230
DOI: 10.1002/(sici)1099-1166(199610)11:10<901::aid-gps409>3.0.co;2-7

No coin nor oath required. For personal study only.

✦ Synopsis

In a randomized placebo crossover controlled study, six patients meeting DSM-111-R criteria for Alzheimer's disease and exhibiting significantly aggressive behaviour were administered carbamazepine (in doses up to 600 mg daily) and placebo, with each treatment period lasting 8 weeks. Levels of aggression as measured by the RAGE scale were significantly reduced compared with placebo ( p < 0.05). The results suggest that carbamazepine is an effective antiaggressive agent in patients with dementia. Recommendations for further studies are made.

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