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Native low-density lipoprotein induces endothelial nitric oxide synthase dysfunction: role of heat shock protein 90 and caveolin-1

✍ Scribed by Kirkwood A Pritchard Jr; Allan W Ackerman; Jingsong Ou; Michelle Curtis; David M Smalley; Jason T Fontana; Michel B Stemerman; William C Sessa


Book ID
114275172
Publisher
Elsevier Science
Year
2002
Tongue
English
Weight
304 KB
Volume
33
Category
Article
ISSN
0891-5849

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## Abstract Hyperglycemia is the hallmark of diabetes mellitus. Poor glycemic control is correlated with increased cardiovascular morbidity and mortality. High glucose can trigger endothelial cell apoptosis by de‐activation of endothelial nitric oxide synthase (eNOS). eNOS was recently demonstrated