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Nasopharyngeal carcinoma, aplastic anemia, and various malignancies in a family: Possible role of Epstein-Barr virus

✍ Scribed by Schimke, R. Neil ;Collins, Debra ;Cross, Donald ;Opitz, John M. ;Reynolds, James F.


Publisher
John Wiley and Sons
Year
1987
Tongue
English
Weight
417 KB
Volume
27
Category
Article
ISSN
0148-7299

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The Epstein-Barr virus (EBV) open reading frame BHRF1, a homologue of the oncogene bcl-2, was cloned from a patient with nasopharyngeal carcinoma (NPC) and overexpressed in Escherichia coli. The resulting recombinant BHRF1 fusion protein, with an apparent molecular weight of 35 KD, was used as antig