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Narciclasine, A Plant Growth Modulator, Shows Anti-Tumoral Activity in Vitro and In Vivo in Human Preclinical Models of Primary and Secondary Brain Tumors

✍ Scribed by F. Lefranc; V. Mathieu; G. Van Goietsenhove; R. Kiss


Book ID
113952966
Publisher
Elsevier
Year
2012
Tongue
English
Weight
248 KB
Volume
77
Category
Article
ISSN
1878-8750

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A derivative of staurosporine (CGP 41 25
✍ Thomas Meyer; Urs Regenass; Doriano Fabbro; Enrica Alteri; Johannes RΓΆusel; Marc πŸ“‚ Article πŸ“… 1989 πŸ› John Wiley and Sons 🌐 French βš– 632 KB

Analogues of staurosporine were synthesized and their ability to inhibit protein kinases was examined. Staurosporine is a potent but non-selective inhibitor of in vitro protein kinase C (PKC) activity (K5, 6.0 nn). The derivative CGP 41 25 I had reduced PKC activity with an IC,, of 50 nn but showed