Anti-tumor activity of a novel EGFR tyrosine kinase inhibitor against human NSCLC in vitro and in vivo
β Scribed by Jing Li; Yan Li; Zhi-qiang Feng; Xiao-guang Chen
- Book ID
- 116335144
- Publisher
- Elsevier Science
- Year
- 2009
- Tongue
- English
- Weight
- 375 KB
- Volume
- 279
- Category
- Article
- ISSN
- 0304-3835
No coin nor oath required. For personal study only.
π SIMILAR VOLUMES
Cultured tumor cell lines, tumor xenografts grown in athymic nude mice, and a murine experimental metastasis model were used to assess the in vitro and in vivo anti-tumor activity of the potent IMP dehydrogenase (IMPDH) inhibitor, mycophenolic acid (MPA), and its morpholinoethyl ester pro-drug, myco
The present report describes the in vitro and in vivo profile of CEP-751, a novel receptor tyrosine kinase inhibitor. CEP-751 at 100 nM inhibits the receptor tyrosine kinase activity of the neurotrophin receptors trkA, trkB and trkC. CEP-751 has no effect on activity of receptors for EGF, IGF-I, ins